Side-to-side symmetry of radioprotein transfer from tissue space to systemic vasculature following subcutaneous injection in normal subjects and patients with breast cancer.
Identifieur interne : 008D97 ( Main/Exploration ); précédent : 008D96; suivant : 008D98Side-to-side symmetry of radioprotein transfer from tissue space to systemic vasculature following subcutaneous injection in normal subjects and patients with breast cancer.
Auteurs : Simon J. Pain [Royaume-Uni] ; Robert W. Barber ; James R. Ballinger ; Chandra K. Solanki ; Susan O'Mahony ; Peter S. Mortimer ; Arnie Purushotham ; A Michael PetersSource :
- European journal of nuclear medicine and molecular imaging [ 1619-7070 ] ; 2003.
Descripteurs français
- KwdFr :
- Bras (), Bras (imagerie diagnostique), Clairance métabolique, Composés organiques du technétium (administration et posologie), Composés organiques du technétium (sang), Femelle, Humains, Immunoglobuline G (administration et posologie), Immunoglobuline G (sang), Lymphoedème (imagerie diagnostique), Lymphoedème (métabolisme), Lymphoedème (sang), Lymphoscintigraphie, Radio-isotopes de l'indium (administration et posologie), Radio-isotopes de l'indium (pharmacocinétique), Radio-isotopes de l'indium (sang), Radiopharmaceutiques (administration et posologie), Radiopharmaceutiques (sang), Reproductibilité des résultats, Sensibilité et spécificité, Système lymphatique (), Système lymphatique (métabolisme), Tumeurs du sein (), Tumeurs du sein (imagerie diagnostique), Épinéphrine (administration et posologie).
- MESH :
- administration et posologie : Composés organiques du technétium, Immunoglobuline G, Radio-isotopes de l'indium, Radiopharmaceutiques, Épinéphrine.
- imagerie diagnostique : Bras, Lymphoedème, Tumeurs du sein.
- métabolisme : Lymphoedème, Système lymphatique.
- pharmacocinétique : Radio-isotopes de l'indium.
- sang : Composés organiques du technétium, Immunoglobuline G, Lymphoedème, Radio-isotopes de l'indium, Radiopharmaceutiques.
- Bras, Clairance métabolique, Femelle, Humains, Lymphoscintigraphie, Reproductibilité des résultats, Sensibilité et spécificité, Système lymphatique, Tumeurs du sein.
English descriptors
- KwdEn :
- Arm (blood supply), Arm (diagnostic imaging), Breast Neoplasms (complications), Breast Neoplasms (diagnostic imaging), Epinephrine (administration & dosage), Female, Humans, Immunoglobulin G (administration & dosage), Immunoglobulin G (blood), Indium Radioisotopes (administration & dosage), Indium Radioisotopes (blood), Indium Radioisotopes (pharmacokinetics), Lymphatic System (blood supply), Lymphatic System (drug effects), Lymphatic System (metabolism), Lymphedema (blood), Lymphedema (diagnostic imaging), Lymphedema (metabolism), Lymphoscintigraphy, Metabolic Clearance Rate, Organotechnetium Compounds (administration & dosage), Organotechnetium Compounds (blood), Radiopharmaceuticals (administration & dosage), Radiopharmaceuticals (blood), Reproducibility of Results, Sensitivity and Specificity.
- MESH :
- chemical , administration & dosage : Epinephrine, Immunoglobulin G, Indium Radioisotopes, Organotechnetium Compounds, Radiopharmaceuticals.
- chemical , blood : Immunoglobulin G, Indium Radioisotopes, Organotechnetium Compounds, Radiopharmaceuticals.
- blood : Lymphedema.
- blood supply : Arm, Lymphatic System.
- complications : Breast Neoplasms.
- diagnostic imaging : Arm, Breast Neoplasms, Lymphedema.
- drug effects : Lymphatic System.
- metabolism : Lymphatic System, Lymphedema.
- chemical , pharmacokinetics : Indium Radioisotopes.
- Female, Humans, Lymphoscintigraphy, Metabolic Clearance Rate, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Quantitative lymphoscintigraphy can be used for investigation of unilateral lymphatic disease of the limbs, such as breast cancer-related lymphoedema (BCRL). Previous studies have compared lymphatic function in the affected limb with that in the unaffected contralateral limb. This study aims to confirm that the assumption of pre-morbid symmetry, never previously demonstrated, is valid. A dual-isotope technique, with bilateral subcutaneous hand injection of polyclonal human immunoglobulin G (HIgG) labelled with either technetium-99m or indium-111, was performed on a total of 37 subjects. The use of two different labels, one for each limb, enabled comparison not only of the rate of clearance from the injection depot, but also of the rate of appearance in venous blood. Results demonstrate clear symmetry between the two arms with respect to both depot clearance and blood appearance rates, as well as the coupling between these two variables. In unilateral lymphatic disease, results of quantitative lymphoscintigraphy should be expressed in relation to the normal arm rather than to an independent control population.
DOI: 10.1007/s00259-003-1135-z
PubMed: 12652333
Affiliations:
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Le document en format XML
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<wicri:regionArea>Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge</wicri:regionArea>
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<author><name sortKey="Barber, Robert W" sort="Barber, Robert W" uniqKey="Barber R" first="Robert W" last="Barber">Robert W. Barber</name>
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<author><name sortKey="Solanki, Chandra K" sort="Solanki, Chandra K" uniqKey="Solanki C" first="Chandra K" last="Solanki">Chandra K. Solanki</name>
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<author><name sortKey="O Mahony, Susan" sort="O Mahony, Susan" uniqKey="O Mahony S" first="Susan" last="O'Mahony">Susan O'Mahony</name>
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<author><name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arm (blood supply)</term>
<term>Arm (diagnostic imaging)</term>
<term>Breast Neoplasms (complications)</term>
<term>Breast Neoplasms (diagnostic imaging)</term>
<term>Epinephrine (administration & dosage)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoglobulin G (administration & dosage)</term>
<term>Immunoglobulin G (blood)</term>
<term>Indium Radioisotopes (administration & dosage)</term>
<term>Indium Radioisotopes (blood)</term>
<term>Indium Radioisotopes (pharmacokinetics)</term>
<term>Lymphatic System (blood supply)</term>
<term>Lymphatic System (drug effects)</term>
<term>Lymphatic System (metabolism)</term>
<term>Lymphedema (blood)</term>
<term>Lymphedema (diagnostic imaging)</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphoscintigraphy</term>
<term>Metabolic Clearance Rate</term>
<term>Organotechnetium Compounds (administration & dosage)</term>
<term>Organotechnetium Compounds (blood)</term>
<term>Radiopharmaceuticals (administration & dosage)</term>
<term>Radiopharmaceuticals (blood)</term>
<term>Reproducibility of Results</term>
<term>Sensitivity and Specificity</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Bras ()</term>
<term>Bras (imagerie diagnostique)</term>
<term>Clairance métabolique</term>
<term>Composés organiques du technétium (administration et posologie)</term>
<term>Composés organiques du technétium (sang)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunoglobuline G (administration et posologie)</term>
<term>Immunoglobuline G (sang)</term>
<term>Lymphoedème (imagerie diagnostique)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Lymphoedème (sang)</term>
<term>Lymphoscintigraphie</term>
<term>Radio-isotopes de l'indium (administration et posologie)</term>
<term>Radio-isotopes de l'indium (pharmacocinétique)</term>
<term>Radio-isotopes de l'indium (sang)</term>
<term>Radiopharmaceutiques (administration et posologie)</term>
<term>Radiopharmaceutiques (sang)</term>
<term>Reproductibilité des résultats</term>
<term>Sensibilité et spécificité</term>
<term>Système lymphatique ()</term>
<term>Système lymphatique (métabolisme)</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (imagerie diagnostique)</term>
<term>Épinéphrine (administration et posologie)</term>
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<term>Immunoglobulin G</term>
<term>Indium Radioisotopes</term>
<term>Organotechnetium Compounds</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term>
<term>Indium Radioisotopes</term>
<term>Organotechnetium Compounds</term>
<term>Radiopharmaceuticals</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Composés organiques du technétium</term>
<term>Immunoglobuline G</term>
<term>Radio-isotopes de l'indium</term>
<term>Radiopharmaceutiques</term>
<term>Épinéphrine</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Arm</term>
<term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arm</term>
<term>Breast Neoplasms</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Bras</term>
<term>Lymphoedème</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphatic System</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Radio-isotopes de l'indium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Indium Radioisotopes</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Composés organiques du technétium</term>
<term>Immunoglobuline G</term>
<term>Lymphoedème</term>
<term>Radio-isotopes de l'indium</term>
<term>Radiopharmaceutiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Lymphoscintigraphy</term>
<term>Metabolic Clearance Rate</term>
<term>Reproducibility of Results</term>
<term>Sensitivity and Specificity</term>
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<term>Clairance métabolique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoscintigraphie</term>
<term>Reproductibilité des résultats</term>
<term>Sensibilité et spécificité</term>
<term>Système lymphatique</term>
<term>Tumeurs du sein</term>
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<front><div type="abstract" xml:lang="en">Quantitative lymphoscintigraphy can be used for investigation of unilateral lymphatic disease of the limbs, such as breast cancer-related lymphoedema (BCRL). Previous studies have compared lymphatic function in the affected limb with that in the unaffected contralateral limb. This study aims to confirm that the assumption of pre-morbid symmetry, never previously demonstrated, is valid. A dual-isotope technique, with bilateral subcutaneous hand injection of polyclonal human immunoglobulin G (HIgG) labelled with either technetium-99m or indium-111, was performed on a total of 37 subjects. The use of two different labels, one for each limb, enabled comparison not only of the rate of clearance from the injection depot, but also of the rate of appearance in venous blood. Results demonstrate clear symmetry between the two arms with respect to both depot clearance and blood appearance rates, as well as the coupling between these two variables. In unilateral lymphatic disease, results of quantitative lymphoscintigraphy should be expressed in relation to the normal arm rather than to an independent control population.</div>
</front>
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<affiliations><list><country><li>Royaume-Uni</li>
</country>
</list>
<tree><noCountry><name sortKey="Ballinger, James R" sort="Ballinger, James R" uniqKey="Ballinger J" first="James R" last="Ballinger">James R. Ballinger</name>
<name sortKey="Barber, Robert W" sort="Barber, Robert W" uniqKey="Barber R" first="Robert W" last="Barber">Robert W. Barber</name>
<name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name>
<name sortKey="O Mahony, Susan" sort="O Mahony, Susan" uniqKey="O Mahony S" first="Susan" last="O'Mahony">Susan O'Mahony</name>
<name sortKey="Peters, A Michael" sort="Peters, A Michael" uniqKey="Peters A" first="A Michael" last="Peters">A Michael Peters</name>
<name sortKey="Purushotham, Arnie" sort="Purushotham, Arnie" uniqKey="Purushotham A" first="Arnie" last="Purushotham">Arnie Purushotham</name>
<name sortKey="Solanki, Chandra K" sort="Solanki, Chandra K" uniqKey="Solanki C" first="Chandra K" last="Solanki">Chandra K. Solanki</name>
</noCountry>
<country name="Royaume-Uni"><noRegion><name sortKey="Pain, Simon J" sort="Pain, Simon J" uniqKey="Pain S" first="Simon J" last="Pain">Simon J. Pain</name>
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</record>
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